Activating Compound | Comment | Organism | Structure |
---|---|---|---|
Calmodulin | - |
Mus musculus | |
receptor activator of nuclear factor kappa B ligand | - |
Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
KN62 | reversible inhibition, causes inhibition of osteoclast formation in vivo | Mus musculus | |
KN93 | reversible inhibition, causes inhibition of osteoclast formation in vivo | Mus musculus | |
additional information | no inhibition of CaMKII by KN92 | Mus musculus |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Ca2+ | required | Mus musculus | |
Mg2+ | - |
Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + protein CREB | Mus musculus | activation by phosphorylation | ADP + phosphorylated protein CREB | - |
? | |
ATP + protein CREB | Mus musculus C57/Bl | activation by phosphorylation | ADP + phosphorylated protein CREB | - |
? | |
ATP + protein ERK | Mus musculus | activation by phosphorylation | ADP + phosphorylated protein ERK | - |
? | |
ATP + protein ERK | Mus musculus C57/Bl | activation by phosphorylation | ADP + phosphorylated protein ERK | - |
? | |
additional information | Mus musculus | CaMK activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand, RANKL, overview | ? | - |
? | |
additional information | Mus musculus C57/Bl | CaMK activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand, RANKL, overview | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q923T9 | C57/Bl mice | - |
Mus musculus C57/Bl | Q923T9 | C57/Bl mice | - |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
BBM cell | receptor activator of nuclear factor kappa B ligand-differentiated, expression of CaMKI and CaMKIIgamma | Mus musculus | - |
bone marrow | - |
Mus musculus | - |
brain | expression of CaMKI, CaMKII alpha, beta, gamma and delta, and CaMKIV | Mus musculus | - |
osteoclast | - |
Mus musculus | - |
RAW264.7 cell | receptor activator of nuclear factor kappa B ligand-differentiated, expression of CaMKI, CaMKIIgamma and also of CaMKIV at minimum level | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
ATP + protein CREB | activation by phosphorylation | Mus musculus | ADP + phosphorylated protein CREB | - |
? | |
ATP + protein CREB | activation by phosphorylation | Mus musculus C57/Bl | ADP + phosphorylated protein CREB | - |
? | |
ATP + protein ERK | activation by phosphorylation | Mus musculus | ADP + phosphorylated protein ERK | - |
? | |
ATP + protein ERK | activation by phosphorylation | Mus musculus C57/Bl | ADP + phosphorylated protein ERK | - |
? | |
additional information | CaMK activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand, RANKL, overview | Mus musculus | ? | - |
? | |
additional information | CaMK activity is required for efficient induction of osteoclast differentiation and bone resorption by receptor activator of nuclear factor kappa B ligand, RANKL, overview | Mus musculus C57/Bl | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
calcium/calmodulin-dependent kinase | - |
Mus musculus |
Cofactor | Comment | Organism | Structure |
---|---|---|---|
ATP | - |
Mus musculus |